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Twenty One, a 4-star hotel in Rome

A memorable experience in the heart of Rome

Hotel Twenty One is a modern 4-star hotel in Rome, the ideal place to spend an unforgettable stay in the Eternal City.

In one of the most sought-after corners of the capital, our hotel is characterized by a modern and elegant décor, comfortable surroundings and a family atmosphere. Hotel Twenty One has 93 rooms furnished to perfection and equipped with all the services you are likely to need.

A stone’s throw from the Vatican, with a picturesque view of the Pincian Hill and the dome of St. Peter’s, our 4-star hotel is in a strategic position to reach all of Rome’s main points of interest. From Hotel Twenty One you can easily explore the renowned beauty spots of Rome on foot, from the Vatican Museums to the Spanish Steps, from Piazza Navona to the Trevi Fountain, with itineraries that are unique in their combination of art, history and culture. Thanks to the nearby underground station, you can also move easily and quickly to the most fashionable streets of the capital for exclusive shopping in the boutiques of Rome.

Whatever the reason for your trip, whether it’s a holiday of leisure and pleasure or for business, Hotel Twenty One is the right choice of place to stay in Rome, a place where you can relax completely.

Best Offers in Rome


Paying immediately is worthwhile! This is a promotion that is ideal for business trips to Rome, but also for a beautiful holiday in the Eternal City. (more…)

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Book now using our booking form and in addition to free cancellation, you will have WiFi, Sky and minibar, all free. (more…)

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Bistro 21, an exclusive restaurant in the centre of Rome

Every day, our Chef offers the best traditional Italian dishes both at lunchtime and dinner. The flavours and aromas of Mediterranean cuisine, top-quality ingredients and loads of passion for an amazing taste experience. We also look forward to seeing you for an aperitif, with fabulous cocktails and an ample buffet.

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Your hotel in the heart of the Eternal City.

Hotel Twenty One is located in the heart of Rome, a strategic position from which to visit the city, halfway between the Vatican Museums and Piazza di Spagna. Extremely convenient for you to reach all of the main points of interest for art, history and culture, but also for business and leisure.

Hotel Twentyone Roma

Via Cola Di Rienzo, 23 | 00192 Rome, Italy
Tel. +39.06.32609607 +39.06.32609557