4-star Hotel in Rome Prati

4-star Hotel
in the heart of Rome

Located on Via Cola di Rienzo in the Prati district, Hotel TwentyOne truly places you at the heart of Rome. Just a short walk from the Vatican, Piazza del Popolo and Lepanto metro station, you can explore the city on foot and return to a modern, welcoming and peaceful setting.
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Central Location
In the Prati district, between the Vatican, Piazza del Popolo and Piazza di Spagna: Rome’s main attractions are within walking distance.
Best online rate
You’ll always get the best available rate and exclusive offers when booking directly on the official website.
4-star amenities
Free Wi-Fi, buffet breakfast, 24-hour reception and modern rooms for business and leisure stays.
Twenty One Hotel | Hotel 4 star in Central Rome
Twenty One Hotel | Hotel 4 star in Central Rome

ABOUT US

Hotel in the heart of central Rome

Located on Via Cola di Rienzo, one of the most elegant streets in Prati, Hotel Twenty One is a 4-star hotel in central Rome that combines contemporary design with warm hospitality. From here, you can easily walk to the Vatican, Castel Sant’Angelo, Piazza del Popolo and the banks of the Tiber River, whilst the Lepanto metro station takes you to Piazza di Spagna and Termini Station in just a few minutes. Whether you’re travelling for leisure or business, you’ll find a strategic base from which to experience Rome without compromising on comfort.

Located between the Vatican and the historic centre

Lepanto metro station just a few minutes’ walk away

Shops, restaurants and amenities on Via Cola di Rienzo

OUR ROOMS

Our rooms

Standard Rooms

Double and Twin Rooms: practical and comfortable options for singles, couples, friends or business travellers in the centre of Rome.
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Deluxe Rooms

Our most exclusive categories offer more spacious rooms, extra amenities and, in some cases, a private terrace with a stunning view of Rome. Perfect for romantic weekends and special stays.
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Family Rooms

Triple or Quadruple Rooms and connecting Family Rooms, with more space and two bathrooms. Ideal for those travelling with children or in small groups who are eager to explore Prati and the historic centre on foot.
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DISCOVER ROME

Rome is within walking distance from our hotel

Every day you can plan a different itinerary starting from Hotel Twenty One: in the morning, you could visit the Vatican and St Peter’s Square; in the afternoon, you could stroll through Piazza del Popolo, Via del Corso and Villa Borghese; in the evening, you could enjoy the bars and restaurants in Prati. The pictures show just a glimpse of what you can experience by choosing our 4-star hotel in the centre of Rome.
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OFFERS & EVENTS

Special Offers and Events

Discover our offers for staying in the centre of Rome and the events taking place just a stone’s throw from the hotel: concerts, exhibitions, and events in the city and the Prati district.

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Book now your next getaway to Rome

Are you planning a romantic weekend, a family holiday or a business trip? Hotel Twenty One offers you a convenient and central location, in the heart of Rome’s Prati district and just a short walk from the Vatican.
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TESTIMONIALS

What our guests say

A joyful family portrait with parents kissing their baby outdoors on a sunny day.
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OUR STATISTICS

Hospitality that speaks for itself

Year after year, Hotel Twenty One is chosen by Italian and international travellers for its central location, 4-star facilities and attentive yet discreet hospitality.

1000+

Stays
Stays per year, including leisure and business

10+

Years
Years of experience in the Prati district
Strategic location
In the heart of Prati, just a short walk from the Vatican, Piazza del Popolo and the Lepanto metro station: Rome is truly at your fingertips.
Staff always available
A team available 24 hours a day, ready to assist you with recommendations on restaurants, itineraries and getting around the city.
Contemporary comfort
Modern rooms, stylish interiors, fast Wi-Fi and communal areas designed for relaxation after a day exploring Rome.
Breakfast and services
A sweet and savoury buffet breakfast, luggage storage, transfers on request, and solutions tailored for families and business travellers.

READY TO BOOK?

Let’s start planning your next stay in Rome here

Send us your dates and the number of guests: we will get back to you with the best available offer, including rooms, deals and services at Hotel Twenty One in the centre of Rome.

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